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Coeliac disease & gluten sensitivity

Epithelial stress enters the dance in coeliac disease

Nature Reviews Gastroenterology & Hepatology volume 12, pages 491–492 (2015)Cite this article

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Coeliac disease is an immune-mediated enteropathy induced by gluten. Generation of gluten-specific CD4+ T cells is necessary but not sufficient to induce overt disease. Now, epithelial stress has been proposed as a distinct factor that synergizes with the anti-gluten adaptive immune response to induce intraepithelial lymphocyte activation and tissue damage.

Refers to Setty, M. et al. Distinct and synergistic contributions of epithelial stress and adaptive immunity to functions of intraepithelial killer cells and active celiac disease. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2015.05.013

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Figure 1: Epithelial stress and adaptive immunity in coeliac disease pathogenesis.

References

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Acknowledgements

The authors are supported by Institut National Pour la Santé et la Recherche and Université Paris Descartes and by grants from la Ligue Contre le Cancer, la Fondation Princesse Grace et l'Association Française des Intolérants au Gluten (AFDIAG). Institut Imagine is recipient of Investissement d'Avenir ANR10-IAHU01.

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  1. INSERM UMR1163, Laboratory of Intestinal Immunity, Université Paris Descartes-Sorbonne Paris Cité, 24 Boulevard du Montparnasse, 75015, Paris, France

    Nadine Cerf-Bensussan & Bertrand Meresse

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  1. Nadine Cerf-Bensussan
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  2. Bertrand Meresse
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Correspondence to Nadine Cerf-Bensussan.

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Cerf-Bensussan, N., Meresse, B. Epithelial stress enters the dance in coeliac disease. Nat Rev Gastroenterol Hepatol 12, 491–492 (2015). https://doi.org/10.1038/nrgastro.2015.120

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