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Coeliac disease

Noncoeliac gluten sensitivity—food for thought

Patients with noncoeliac gluten sensitivity (NCGS) can experience a range of gastrointestinal and extraintestinal symptoms. A study has now demonstrated that gluten is independently associated with depression in patients with NCGS. NCGS-associated depression might share similar pathophysiological mechanisms to other neurological manifestations observed in gluten-related disorders, such as ataxia and encephalopathy.

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References

  1. Volta, U. & De Giorgio, R. New understanding of gluten sensitivity. Nat. Rev. Gastroenterol. Hepatol. 9, 295–299 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Catassi, C. et al. Non-celiac gluten sensitivity: the new frontier of gluten related disorders. Nutrients 5, 3839–3853 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Peters, S. L., Biesiekierski, J. R., Yelland, G. W., Muir, J. G. & Gibson, P. R. Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity—an exploratory clinical study. Aliment. Pharmacol. Ther. 39, 1104–1112 (2014).

    Article  CAS  PubMed  Google Scholar 

  4. Brottveit, M., Vandvik, P. O., Wojniusz, S., Løvik, A., Lundin, K. E. & Boye, B. Absence of somatization in non-coeliac gluten sensitivity. Scand. J Gastroenterol. 47, 770–777 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Hadjivassiliou, M. et al. Gluten sensitivity: from gut to brain. Lancet Neurol. 9, 318–330 (2010).

    Article  CAS  PubMed  Google Scholar 

  6. Hadjivassiliou, M. et al. Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology 80, 1740–1745 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. Kalaydjian, A. E., Eaton, W., Cascella, N. & Fasano, A. The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatr. Scand. 113, 82–90 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. Cascella, N. G. et al. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr. Bull. 37, 94–100 (2011).

    Article  PubMed  Google Scholar 

  9. Dickerson, F. et al. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol. Psychiatry 68, 100–104 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. Cascella, N. G. et al. Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophr. Bull. 39, 867–871 (2013).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Imran Aziz or Marios Hadjivassiliou.

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Aziz, I., Hadjivassiliou, M. Noncoeliac gluten sensitivity—food for thought. Nat Rev Gastroenterol Hepatol 11, 398–399 (2014). https://doi.org/10.1038/nrgastro.2014.91

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