In this proof-of-concept study, mice were immunized with a vaccine candidate obtained by purification and ultraviolet-irradiation of adenovirus 36 (Ad36), which is associated with obesity. 14 weeks after subsequent injection of live Ad36, unvaccinated mice had 17% greater body weight and 20% more epididymal fat than vaccinated mice. Serum levels of proinflammatory cytokines and infiltrated immune cells in fat tissue were also decreased in vaccinated compared with unvaccinated mice.
References
Na, H.-N. & Nam, J.-H. Proof-of-concept for a virus-induced obesity vaccine; vaccination against the obesity agent adenovirus 36. Int. J. Obes. (Lond.) 10.1038/ijo.2014.41
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Vaccination protects against virus-induced obesity. Nat Rev Gastroenterol Hepatol 11, 330 (2014). https://doi.org/10.1038/nrgastro.2014.80
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DOI: https://doi.org/10.1038/nrgastro.2014.80