Patients with nonresponsive coeliac disease (NRCD) have persistent villous atrophy despite adhering to a gluten-free diet. A noninvasive approach to identify these patients has now been reported by Spatola et al. Measurement of anti-dGP (deamidated gliadin peptide) IgG antibodies using ELISA led to accurate, noninvasive discrimination between patients with NRCD (n = 15) and those with responsive coeliac disease (n = 45; 87% sensitivity, 89% specificity). Of note, dGP antibody titre correlated with mucosal damage so it could be used to monitor histological improvement.
References
Spatola, B. N. et al. Persistence of elevated deamidated gliadin peptide antibodies on a gluten-free diet indicates nonresponsive coeliac disease. Aliment. Pharmacol. Ther. 10.1111/apt.12603
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Noninvasive approach to identify nonresponsive coeliac disease. Nat Rev Gastroenterol Hepatol 11, 74 (2014). https://doi.org/10.1038/nrgastro.2014.4
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DOI: https://doi.org/10.1038/nrgastro.2014.4
