Theriot et al. have shown that the mouse gut microbiome and metabolome undergo substantial changes in response to antibiotic treatment and that these changes support the germination and growth of Clostridium difficile. Treatment with cefoperazone altered the composition and diversity of the gut microbiome and enriched the metabolic environment with primary bile acids and carbohydrates.
References
Theriot, C. M. et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat. Commun. 10.1038/ncomms4114
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Antibiotics shift mouse gut microbiome and metabolome. Nat Rev Gastroenterol Hepatol 11, 140 (2014). https://doi.org/10.1038/nrgastro.2014.23
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DOI: https://doi.org/10.1038/nrgastro.2014.23
