New research from Anstee and colleagues has confirmed that a common nonsynonymous single nucleotide polymorphism in TM6SF2 (rs58542926 c.449 C>T, Glu167Lys) is associated with NAFLD and causally related to a signal assigned to NCAN on chromomose 19 by a genome-wide association study. By looking at two cohorts that included histologically characterized steatosis, steatohepatitis, fibrosis and cirrhosis, they have also established a new association between the TM6SF2 polymorphism and hepatic fibrogenesis.
References
Liu, Y.-L. et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat. Commun. 5, 4309 (2014)
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Single nucleotide polymorphism in TM6SF2 is clinically relevant to progression of hepatic fibrosis in NAFLD. Nat Rev Gastroenterol Hepatol 11, 516 (2014). https://doi.org/10.1038/nrgastro.2014.138
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DOI: https://doi.org/10.1038/nrgastro.2014.138
