Treatment of patients with steroid-refractory ulcerative colitis is still a challenge for physicians. A recent study has evaluated the effectiveness and safety of sequential rescue therapies in this subgroup of patients.
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References
Protic, M. et al. The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. J. Crohns Colitis http://dx.doi.org/10.1016/j.crohns.2014.05.004.
Dinesen, L. C. et al. The pattern and outcome of acute severe colitis. J. Crohns Colitis 4, 431–437 (2010).
Dignass, A. et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management. J. Crohns Colitis 6, 991–1030 (2012).
Laharie, D. et al. Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Lancet 380, 1909–1915 (2012).
Cottone, M. et al. Clinical course of ulcerative colitis. Dig. Liver Dis. 40 (Suppl. 2), S247–S252 (2008).
Mehta, S. J., Silver, A. R. & Lindsay, J. O. Review article: strategies for the management of chronic unremitting ulcerative colitis. Aliment. Pharmacol. Ther. 38, 77–97 (2013).
Chaparro, M. et al. Infliximab salvage therapy after failure of ciclosporin in corticosteroid-refractory ulcerative colitis: a multicentre study. Aliment. Pharmacol. Ther. 35, 275–283 (2012).
Leblanc, S. et al. Successive treatment with cyclosporine and infliximab in steroid-refractory ulcerative colitis. Am. J. Gastroenterol. 106, 771–777 (2011).
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P.G. receives honoraria for speaking from Abbvie, Ferring and MSD, and acts as a consultant for Hospira and Takeda. F.R. receives honoraria for speaking from Abbvie, Ferring and MSD, and acts as a consultant for Takeda.
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Gionchetti, P., Rizzello, F. Sequential rescue therapy in steroid-refractory ulcerative colitis. Nat Rev Gastroenterol Hepatol 11, 521–523 (2014). https://doi.org/10.1038/nrgastro.2014.126
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DOI: https://doi.org/10.1038/nrgastro.2014.126