Age profoundly affects the fibrogenic response to liver injury, according to findings from a mouse model. Acute liver injury was greater in old mice (18 months old) than in middle-aged mice (9 months old). The fibrogenic response to chronic liver injury was also greater in old livers when compared with middle-aged livers. A greater number of macrophages (which are thought to have a role in fibrogenesis) were found in the younger mice and livers than in the older mice and livers, suggesting that macrophage recruitment and dynamics have a role in age-related fibrotic disease.
ORIGINAL RESEARCH PAPER
Collins, B. C. et al. Association of age dependent liver injury and fibrosis with immune cell populations. Liver Int. doi:19.1111/liv.12202
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Liver injury—age matters. Nat Rev Gastroenterol Hepatol 10, 320 (2013). https://doi.org/10.1038/nrgastro.2013.82
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DOI: https://doi.org/10.1038/nrgastro.2013.82