Dulak et al. performed exome sequencing in 149 oesophageal adenocarcinoma samples, and 15 of these samples were subjected to whole-genome sequencing. 26 significantly mutated genes were identified (of which five were already known to have a role in this cancer). The newly identified genes include chromatin-modifying factors as well as upstream modulators of the RAC1 GTPase. These results could help in the quest for new therapeutic targets for oesophageal adenocarcinoma.
ORIGINAL RESEARCH PAPER
Dulak, A. M. et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat. Genet. doi:10.1038/ng.2591
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Mutational signature of oesophageal adenocarcinoma revealed. Nat Rev Gastroenterol Hepatol 10, 258 (2013). https://doi.org/10.1038/nrgastro.2013.65
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DOI: https://doi.org/10.1038/nrgastro.2013.65
