The balance between receptors CXCR7 and CXCR4 in liver sinusoidal endothelial cells determines whether regeneration or fibrosis results after liver injury. In mouse models of liver injury, pro-regenerative CXCR7-dependent signalling was induced by acute injury, but CXCR7 was suppressed and pro-fibrotic CXCR4 upregulated by chronic injury. Ding et al. believe “These results provide a therapeutic roadmap to achieve hepatic regeneration without provoking fibrosis.”
References
Ding, B.-S. et al. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 10.1038/nature12681
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Insight gained into how regeneration and fibrosis in the liver are balanced in response to injury. Nat Rev Gastroenterol Hepatol 11, 2 (2014). https://doi.org/10.1038/nrgastro.2013.251
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DOI: https://doi.org/10.1038/nrgastro.2013.251
