Fibrosis patterns typically differ between adults and children with NAFLD (centrilobular in adults, portal in children). Skoien et al. investigated how fibrosis pattern related to histological parameters in NAFLD. 68.4% of children had portal fibrosis (associated with ductular reaction), whereas 28.9% had 'adult' centrilobular fibrosis (associated with lobular inflammation and ballooning). Traditional markers of disease activity and hepatoceullar injury do not seem to apply to paediatric NAFLD. The authors propose that this heterogeneity in fibrosis patterns indicates the presence of several fibrogenic mechanisms in NAFLD.
ORIGINAL RESEARCH PAPER
Skoien, R. et al. Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways. Liver Int. doi:10.1111/liv.12100
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Are there multiple fibrogenic pathways in NAFLD?. Nat Rev Gastroenterol Hepatol 10, 128 (2013). https://doi.org/10.1038/nrgastro.2013.23
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DOI: https://doi.org/10.1038/nrgastro.2013.23
