Genomic analysis of intrahepatic cholangiocarcinoma (ICC) samples (from 149 patients) has revealed two distinct ICC classes, each distinguishable by their molecular signature and outcomes. The 'proliferation' class (62% of ICCs) were characterized by, among others, activation of oncogenic signalling pathways as well as KRAS and BRAF mutations and, importantly, associated with poor outcome. The remaining 38% of ICCs were designated the 'inflammation' group, characterized by activation of inflammatory signalling.
ORIGINAL RESEARCH PAPER
Sia, D. et al. Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology doi:10.1038/j.gastro.2013.01.001
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Genomic analysis reveals two classes of intrahepatic cholangiocarcinoma. Nat Rev Gastroenterol Hepatol 10, 128 (2013). https://doi.org/10.1038/nrgastro.2013.21
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DOI: https://doi.org/10.1038/nrgastro.2013.21
