Three new genetic associations—19p13 in CRTC1, 9q22 in BARX1 and 3p14 near FOXP1—have been identified for Barrett oesophagus and oesophageal adenocarcinoma, supporting the role for a genetic component in the development of these diseases. In this genome-wide association study, Levine et al. compared 2,390 oesophageal adenocarcinoma cases and 3,175 precancerous Barrett oesophagus cases with 10,120 controls.
References
Levine, D. M. et al. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. Nat. Genet. 10.1038/ng.2796
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New susceptibility loci identified for Barrett oesophagus and oesophageal adenocarcinoma. Nat Rev Gastroenterol Hepatol 10, 695 (2013). https://doi.org/10.1038/nrgastro.2013.207
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DOI: https://doi.org/10.1038/nrgastro.2013.207
