An analysis of Taiwan's National Health Insurance research database has found that long-term use of low-dose aspirin (50–150 mg per day) is associated with a reduced incidence of colorectal cancer (CRC) in patients with high cardiovascular risk. Aspirin users were matched with nonusers and were followed up for a median of 8.9 years. Over this time, 129 nonusers and 14 users of aspirin developed CRC, which corresponds to incidence rates of 180.43 and 79.42 per 100,000 person-years, respectively.