Sung and colleagues have provided a rationale for noninvasive screening of atrophic gastritis with stomach-specific biomarkers. For example, plasma levels of pepsinogen I and/or the pepsinogen I:pepsinogen II ratio are always low in atrophic gastritis of the corpus and fundus. In addition, fasting levels of gastrin-17 are high in atrophic gastritis of the corpus and fundus, but low or not elevated if the gastritis is in the antrum and corpus.
ORIGINAL RESEARCH PAPER
Agréus, L. et al. Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. Scand. J. Gastroenterol. 47, 136–147 (2012)
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Noninvasive diagnosis and screening of atrophic gastritis. Nat Rev Gastroenterol Hepatol 9, 124 (2012). https://doi.org/10.1038/nrgastro.2012.8
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DOI: https://doi.org/10.1038/nrgastro.2012.8
