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Biliary tract

Is there a role for neoadjuvant and adjuvant therapy in biliary cancer?

A retrospective analysis of adjuvant and neoadjuvant therapy in patients with resectable biliary tract adenocarcinoma shows they confer no survival advantage in the treated groups, leading the authors to conclude they have no benefit. However, the study design does not allow definitive conclusions to be drawn about these treatments.

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References

  1. Glazer, E. S., Liu, P., Abdalla, E. K. Vauthey, J. N. & Curley, S. A. Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins. J. Gastrointest. Surg. 16, 1666–1671 (2012).

    Article  Google Scholar 

  2. Horgan, A. M., Amir, E., Walter, T. & Knox, J. J. Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J. Clin. Oncol. 30, 1934–1940 (2012).

    Article  Google Scholar 

  3. Neoptolomos, J. P. et al. Effect of adjuvant chemotherapy with fluoracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 308, 147–156 (2012).

    Article  Google Scholar 

  4. Valle, J. et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362, 1273–1281 (2010).

    Article  CAS  Google Scholar 

  5. Jarnagin, W. R. et al. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables and clinical outcome. J. Clin. Oncol. 24, 1152–1160 (2006).

    Article  CAS  Google Scholar 

  6. Rocha, F. et al. Intraductal papillary neoplasm of the bile duct (IPNB): a biliary equivalent to IPMN of the pancreas? Hepatology http://dx.doi.org/10.1002/hep.25786

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Jarnagin, W. Is there a role for neoadjuvant and adjuvant therapy in biliary cancer?. Nat Rev Gastroenterol Hepatol 9, 622–623 (2012). https://doi.org/10.1038/nrgastro.2012.186

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