The 2005 annual disease burden of HEV genotype 1 and 2 infection has been estimated for 71% of the world's population (9 of 21 regions defined for the GBD 2010 study). Estimates include 20.1 million incident HEV infections, 3.3 million symptomatic cases, 70,000 deaths and 3,000 stillbirths. The probability of symptomatic disease if infected is estimated at 0.198, whereas the probability of death given symptomatic disease is estimated at 0.019 for nonpregnant cases and 0.198 for pregnant cases.