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The gut microbiota in 2011

Translating the microbiota to medicine

Interest in the gut microbiota has escalated with growing appreciation of the role of indigenous microbes in the health of the host and in the pathogenesis of several intestinal and extraintestinal disorders. The microbiota has become a plausible target for drug and dietary therapy and a repository from which bioactive agents or new drugs can be mined.

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Figure 1: Clinical importance of the gut microbiota.

References

  1. Arumugam, M. et al. Enterotypes of the human gut microbiome. Nature 473, 174–180 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wu, G. U. et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 334, 105–108 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shanahan, F. & Murphy, E. The hybrid science of diet, microbes, and metabolic health. Am. J. Clin. Nutr. 94, 1–2 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57–63 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228–231 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bloom, S. M. et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 9, 390–403 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745–757 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Round, J. L. et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332, 974–977 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Yan, F. et al. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J. Clin. Invest. 121, 2242–2253 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rea, M. C. et al. Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4639–4644 (2011).

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

F. S. is supported, in part, by Science Foundation Ireland.

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F. Shanahan has received grant/research support from Alimentary Health Ltd, for whom he is also a stockholder/director and a patent holder/applicant. He is also a consultant for and has received grant/research support from GlaxoSmithKline and Procter & Gamble. The content of this paper was neither influenced nor constrained by that fact.

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Shanahan, F. Translating the microbiota to medicine. Nat Rev Gastroenterol Hepatol 9, 72–74 (2012). https://doi.org/10.1038/nrgastro.2011.250

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