The FTO gene contains a susceptibility locus for obesity. To determine if physical activity could attenuate the association of FTO with obesity risk, Tuomas Kilpeläinen et al. conducted a meta-analysis of data from 218,166 adults and 19,268 children. The association of FTO with the odds of obesity was attenuated by 27% in physically active adults, although no such effect was found in children.
ORIGINAL RESEARCH PAPER
Kilpeläinen, T. O. et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 8, e1001116
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Physical activity can attenuate risk of obesity. Nat Rev Gastroenterol Hepatol 9, 6 (2012). https://doi.org/10.1038/nrgastro.2011.231
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DOI: https://doi.org/10.1038/nrgastro.2011.231
