Chronic HCV infection can lead to cognitive impairment, but whether the brain is a site of HCV replication and subsequent neuroinflammation is not clear. In a pilot study of patients with biopsy-proven mild chronic HCV and healthy controls, PET revealed microglial activation, which positively correlated with HCV viremia and altered cerebral metabolism, in the brains of patients with mild hepatitis C.
ORIGINAL RESEARCH PAPER
Grover, V. P. B. et al. Cerebral microglial activation in patients with hepatitis C: in vivo evidence of neuroinflammation. J. Viral Hepatitis doi:10.1111/j.1365-2893.2011.01510.x
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HCV activates microglia. Nat Rev Gastroenterol Hepatol 8, 661 (2011). https://doi.org/10.1038/nrgastro.2011.220
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DOI: https://doi.org/10.1038/nrgastro.2011.220