Abnormal bacterial colonization and activation of innate immunity by lipopolysaccharide (LPS) probably have a role in the pathogenesis of necrotizing enterocolitis. In a rodent model of necrotizing enterocolitis, high concentrations of LPS-binding protein (LBP) promoted wound healing and decreased levels of TLR4 (a marker of inflammation). Futher studies are now warranted to investigate this potential therapeutic strategy.
ORIGINAL RESEARCH PAPER
Richter, J. M. et al. Lipopolysaccharide binding protein enables intestinal epithelial restitution despite lipopolysaccharide exposure. J. Pediatr. Gastroenterol. Nutr. doi:10.1097/MPG.0b013e31823a895a
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LBP might promote intestinal wound healing. Nat Rev Gastroenterol Hepatol 8, 661 (2011). https://doi.org/10.1038/nrgastro.2011.219
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DOI: https://doi.org/10.1038/nrgastro.2011.219
