Peyrin-Biroulet and colleagues have identified a mechanism by which hyperplasia of mesenteric fat may contribute to the inflammatory response in patients with Crohn's disease. The researchers found that local inflammation and bacterial translocation to mesenteric fat stimulates the production of C reactive protein (which is used as a marker of disease activity) by mesenteric adipocytes.
ORIGINAL RESEARCH PAPER
Peyrin-Biroulet, L. et al. Mesenteric fast as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease. Gut doi:10.1136/gutjnl-2011-300370
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Mesenteric fat, bacterial translocation, C reactive protein and Crohn's disease. Nat Rev Gastroenterol Hepatol 8, 658 (2011). https://doi.org/10.1038/nrgastro.2011.195
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DOI: https://doi.org/10.1038/nrgastro.2011.195
