Despite consistent reports of an inverse association between NSAIDs and esophageal adenocarcinoma, a large population-based case–control cohort study has found little support for an inverse association between NSAIDs and Barrett esophagus. Information on intake of aspirin and non-aspirin NSAIDs was collected over a 5-year period in patients with non-dysplastic Barrett esophagus, patients with dysplastic Barrett esophagus, 'inflammation' controls and population controls. Whether NSAIDs prevent the onset of Barrett esophagus is a question that the authors say remains open.
ORIGINAL RESEARCH PAPER
Thrift, A. P. et al. The use of nonsteroidal anti-inflammatory drugs and the risk of Barrett's oesophagus. Aliment. Pharmacol. Ther. 34, 1235–1244 (2011)
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NSAIDs not inversely associated with Barrett esophagus. Nat Rev Gastroenterol Hepatol 8, 658 (2011). https://doi.org/10.1038/nrgastro.2011.193
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DOI: https://doi.org/10.1038/nrgastro.2011.193