Patients with chronic HCV often have cross-reactive neutralizing agents but are unable to clear the virus, possibly because the HCV virions are able to avoid lysis. A study has shown that cultured HCV particles incorporate host CD59, a regulator of lysis by complement activation, into their cell membrane. These virions were able to resist antibody-dependent complement-mediated lysis. Addition of CD59 blockers to the culture reversed this phenomenon.
ORIGINAL RESEARCH PAPER
Amet, T. et al. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology doi: 10.1002/hep.24686
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HCV virions incorporate host regulators to avoid lysis. Nat Rev Gastroenterol Hepatol 8, 601 (2011). https://doi.org/10.1038/nrgastro.2011.186
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DOI: https://doi.org/10.1038/nrgastro.2011.186
