Despite numerous trials, the question of whether to use ciclosporin or tacrolimus treatment following liver transplantation in patients with HCV infection is still unresolved. A large retrospective analysis now indicates that tacrolimus is preferable; however, several limitations of this study must be considered.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Selzner, N., Grant, D. R., Shalev, I. & Levy, G. A. The immunosuppressive pipeline: meeting unmet needs in liver transplantation. Liver Transpl. 16, 1359–1372 (2010).
Samuel, D. et al. Report of the Monothematic EASL Conference on Liver Transplantation for Viral Hepatitis (Paris, France, January 12–14, 2006). J. Hepatol. 45, 127–143 (2006).
Lake, J. R. The role of immunosuppression in recurrence of hepatitis C. Liver Transpl. 9, S63–S66 (2003).
Irish, W., Arcona, S., Bowers, D. & Trotter, J. Cyclosporine versus Tacrolimus treated liver transplant recipient s with chronic hepatitis C: Outcomes analysis of the UNOS/OPTN Database. Am. J. Transplant. doi:10.1111/j.1600-6143.2011.03508.x.
Berenguer, M., Royuela, A. & Zamora, J. Immunosuppression with calcineurin inhibitors in regards to the outcome of HCV recurrence after liver transplantation: results of a meta-analysis. Liver Transpl. 13, 21–29 (2007).
Levy, G. et al. Results of list2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation 77, 1632–1638 (2004).
O'Grady, J. G. et al. Randomized controlled trial of tacrolimus versus microemulsified cyclosporine (TMC) in liver transplantation: poststudy surveillance to 3 years. Am. J. Transplant. 7, 137–141 (2007).
Berenguer, M. et al. Effect of calcineurin inhibitors in the outcome of liver transplantation in hepatitis C virus-positive recipients. Transplantation 90, 1204–1209 (2010).
Foxton, M. R. et al. The impact of diabetes mellitus on fibrosis progression in patients transplanted for hepatitis, C. Am. J. Transplant. 6, 1922–1929 (2006).
Berenguer, M. Systematic review of the treatment of established recurrent hepatitis C with pegylated interferon in combination with ribavirin. J. Hepatol. 9, 274–287 (2008).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Berenguer, M. Ciclosporin versus tacrolimus for HCV transplant recipients. Nat Rev Gastroenterol Hepatol 8, 422–424 (2011). https://doi.org/10.1038/nrgastro.2011.124
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2011.124
This article is cited by
-
Virus–drug interactions—molecular insight into immunosuppression and HCV
Nature Reviews Gastroenterology & Hepatology (2012)