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How should classic Whipple disease be managed?

Nature Reviews Gastroenterology & Hepatology volume 7, pages 246–248 (2010)Cite this article

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The optimal treatment for classic Whipple disease has not yet been determined. A recent study reported encouraging results for initial treatment with intravenous ceftriaxone or meropenem followed by long-term treatment with oral trimethoprim–sulfamethoxazole. However, discrepancies in the failure and/or relapse rates associated with trimethoprim–sulfamethoxazole show that this regimen may not be optimal.

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Figure 1: Very late relapse in a patient with classic Whipple disease.

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  1. D. Raoult didier.raoult@gmail.com

Authors and Affiliations

  1. Unité des Rickettsies, CNRS-IRD UMR 6236, IFR 48, Université de la Méditerranée, Faculté de Médecine, 27 Boulevard Jean Moulin, 13005, Marseille, France

    Florence Fenollar & Didier Raoult

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  1. Florence Fenollar
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  2. Didier Raoult
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Fenollar, F., Raoult, D. How should classic Whipple disease be managed?. Nat Rev Gastroenterol Hepatol 7, 246–248 (2010). https://doi.org/10.1038/nrgastro.2010.46

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