Despite steady improvement in survival after variceal bleeding in patients with cirrhosis, bleeding-related mortality remains high. Current treatment recommendations utilize a step-up strategy, in which only patients who rebleed despite drug and endoscopic therapy undergo TIPS (transjugular intrahepatic portosystemic shunt) implantation; however, in patients who are at high risk of rebleeding, early use of TIPS might greatly reduce mortality.
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Rössle, M. Early TIPS in patients with cirrhosis and variceal bleeding. Nat Rev Gastroenterol Hepatol 7, 536–538 (2010). https://doi.org/10.1038/nrgastro.2010.147
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DOI: https://doi.org/10.1038/nrgastro.2010.147
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