A confident and efficient diagnosis of IBS is an important aspect of clinical gastroenterology. How far to investigate a patient with typical IBS symptoms has been the subject of a number of clinical guidelines. A recent study has recommended, somewhat provocatively, that investigation for pancreatic exocrine insufficiency should be added to the tests undertaken in patients with suspected diarrhea-predominant IBS who are referred to a gastroenterologist.
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References
Leeds, J. S. et al. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin. Gastroenterol. Hepatol. 8, 433–438 (2010).
Thompson, W. G. et al. Functional bowel disorders and functional abdominal pain. Gut 45 (Suppl. 2), II43–II47 (1999).
Drossman, D. A. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130, 1377–1390 (2006).
Spiller, R. et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56, 1770–1798 (2007).
American College of Gastroenterology Task Force on Irritable Bowel Syndrome et al. An evidence-based position statement on the management of irritable bowel syndrome. Am. J. Gastroenterol. 104 (Suppl. 1), S1–S35 (2009).
Lankisch, P. G. et al. Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. Gut 42, 551–554 (1998).
Lankisch, P. G. Now that faecal elastase is available in the United States, should clinicians start using it? Curr. Gastroenterol. Rep. 6, 126–131 (2004).
Etemad, B. & Whitcomb, D. C. Chronic pancreatitis; diagnosis, classification and new genetic developments. Gastroenterology 120, 682–707 (2001).
Olsen, T. S. The incidence and clinical relevance of chronic inflammation in the pancreas in autopsy material. Acta Pathol. Microbiol. Scand. A 86, 361–365 (1978).
Gupta, V. & Toskes, P. P. Diagnosis and management of chronic pancreatitis. Postgrad. Med. J. 81, 491–497 (2005).
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Kellow, J. Do we need to exclude exocrine pancreatic insufficiency in IBS?. Nat Rev Gastroenterol Hepatol 7, 479–480 (2010). https://doi.org/10.1038/nrgastro.2010.115
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DOI: https://doi.org/10.1038/nrgastro.2010.115
