Many patients with chronic constipation have a poor quality of life and are dissatisfied with laxative treatment. Findings from a multicenter, randomized, placebo-controlled, phase III study have demonstrated the beneficial effects of the 5-hydroxytryptamine 4 receptor agonist, prucalopride, for chronic constipation and associated symptoms. This drug represents the newest addition to the medical armamentarium for this disorder.
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Bassotti, G., Villanacci, V. Prucalopride for chronic constipation. Nat Rev Gastroenterol Hepatol 6, 324–325 (2009). https://doi.org/10.1038/nrgastro.2009.81
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DOI: https://doi.org/10.1038/nrgastro.2009.81
