The migration route of modern humans out of Africa into Europe and Asia 50,000–100,000 years ago has remained an unresolved question, with conflicting historical, archaeological and genetic evidence for either a Northern (via Egypt and Sinai) or Southern (via Ethiopia and the Arabian Peninsula) route. Pagani et al. now provide support for a Northern migration route, based on analysis of the whole-genome sequences of 100 Egyptians and 125 Ethiopians. They further estimate the timing of the divergence of modern Eurasians from Egyptians and Ethiopians at 55,000 and 65,000 years ago, respectively.