The diverse origins of the human gene pool

Abstract

Analyses of the genomes of Neanderthals and Denisovans, the closest evolutionary relatives of present-day humans, suggest that our ancestors were part of a web of now-extinct populations linked by limited, but intermittent or sometimes perhaps even persistent, gene flow.

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References

  1. 1

    Prüfer, K. et al. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 505, 43–49 (2014).

    Article  Google Scholar 

  2. 2

    Meyer, M. et al. A high-coverage genome sequence from an archaic Denisovan individual. Science 338, 222–226 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Hedrik, P. W. Adaptive introgression in animals: examples and comparison to new mutation and standing variation as sources of adaptive variation. Mol. Ecol. 22, 4606–4618 (2013).

    Article  Google Scholar 

  4. 4

    Racimo, F. et al. Evidence for archaic adaptive introgression in humans. Nature Rev. Genet. 16, 359–371 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Pääbo, S. The human condition — a molecular approach. Cell 157, 216–226 (2014).

    Article  Google Scholar 

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Correspondence to Svante Pääbo.

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The author declares no competing financial interests.

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Ancient genomes database

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Pääbo, S. The diverse origins of the human gene pool. Nat Rev Genet 16, 313–314 (2015). https://doi.org/10.1038/nrg3954

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