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Population genetics

The African Genome Variation Project

Nature Reviews Genetics volume 16, pages 68–69 (2015)Cite this article

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insights into population migrations and admixture, as well as providing a resource that can be used to design and interpret genomic studies

Migration, selection and drift have contributed to genetically structured human populations, and dissecting the patterns of this variation can lead to clues regarding disease. In this study, the AGVP first used the HumanOmni2.5M genotyping array to examine genetic diversity of 1,481 individuals from 18 ethno-linguistic groups from sub-Saharan Africa. Genetic differentiation was found to be fairly modest, with a low level of differentiation between the Niger-Congo language-speaking populations, which reflects the Bantu expansion — a population migration that occurred 3,000–5,000 years ago.

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References

  1. Gurdasani, D et al. The African Genome Variation Project shapes medical genetics in Africa. Nature http://dx.doi.org/10.1038/nature13997 (2014)

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  1. Bryony Jones
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Jones, B. The African Genome Variation Project. Nat Rev Genet 16, 68–69 (2015). https://doi.org/10.1038/nrg3886

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