The concept of metabolically healthy obesity (MHO) suggests that obesity might be a benign condition. This view has been challenged by a recent study demonstrating that, among 3.5 million individuals, those with MHO still have a higher risk of cardiovascular diseases than individuals who are metabolically healthy and normal weight.
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References
GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N. Engl. J. Med. 377, 13–27 (2017).
World Health Organization. Obesity and overweight: fact sheet. WHO www.who.int/mediacentre/factsheets/fs311/en/ (2016).
Blüher, M. Are metabolically healthy obese individuals really healthy? Eur. J. Endocrinol. 171, R209–R219 (2014).
Stefan, N. et al. Metabolically healthy obesity: the low-hanging fruit in obesity treatment? Lancet Diabetes Endocrinol. http://dx.doi.org/10.1016/S2213-8587(17)30292-9 (2017).
Mørkedal, B. et al. Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trøndelag Health Study), Norway. J. Am. Coll. Cardiol. 63, 1071–1078 (2014).
Caleyachetty, R. et al. Metabolically healthy obese and incident cardiovascular disease events among 3.5 million men and women. J. Am. Coll. Cardiol. 70, 1429–1437 (2017).
Weiss, E. P. et al. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial. Am. J. Clin. Nutr. 104, 576–586 (2016).
van Vliet-Ostaptchouk, J. V. et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies. BMC Endocr. Disord. 14, 9 (2014).
Klöting, N. et al. Insulin-sensitive obesity. Am. J. Physiol. Endocrinol. Metab. 299, E506–E515 (2010).
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Blüher, M. The myth of innocent obesity. Nat Rev Endocrinol 13, 691–692 (2017). https://doi.org/10.1038/nrendo.2017.146
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DOI: https://doi.org/10.1038/nrendo.2017.146
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