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Endocrine disruptors

Flame retardants and increased risk of thyroid cancer

Nature Reviews Endocrinology volume 13, pages 627628 (2017) | Download Citation

Household dust contaminated with common flame retardants used in everyday household items has been found to be associated with increased risk of developing smaller, as well as more aggressive forms of papillary thyroid cancer in humans. These findings emphasize the need to consider the exposome when evaluating the increased incidence of thyroid cancer.

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  1. 1.

    et al. Trends in thyroid cancer incidence and mortality in the United States, 1974–2013. JAMA 317, 1338–1348 (2017).

  2. 2.

    et al. Association of polybrominated diphenylethers (PBDEs) and hydroxylated metabolites (OH-PBDEs) serum levels with thyroid function in thyroid cancer patients. Environ. Res. 159, 1–8 (2017).

  3. 3.

    et al. Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: a case–control study. Environ. Int. 107, 235–242 (2017).

  4. 4.

    et al. Critical factors in assessing exposure to PBDEs via house dust. Environ. Int. 34, 1085–1091 (2008).

  5. 5.

    , & Increasing incidence of differentiated thyroid cancer in the United States, 1988–2005. Cancer 115, 3801–3807 (2009).

  6. 6.

    et al. Associations between urinary diphenyl phosphate and thyroid function. Environ. Int. 101, 158–164 (2017).

  7. 7.

    & Polybrominated diphenyl ethers (PBDEs) in the indoor and outdoor environments — a review on occurrence and human exposure. Environ. Pollut. 169, 217–229 (2012).

  8. 8.

    et al. Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol. 4, 996–1003 (2016).

  9. 9.

    et al. Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J. Clin. Endocrinol. Metab. 100, 1256–1266 (2015).

  10. 10.

    Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile. EFSA J. 11, 3293 (2013).

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The authors thank C. Luongo for helpful discussions on thyroid cancer.

Author information


  1. CNRS/UMR7221, Muséum National d'Histoire Naturelle/Université Paris-Sorbonne, 7 rue Cuvier, 75005 Paris, France.

    • Bilal B. Mughal
    •  & Barbara A. Demeneix


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Competing interests

B.A.D. is a co-founder of WatchFrog. B.B.M. declares no competing interests.

Corresponding author

Correspondence to Barbara A. Demeneix.

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