Women with nonfunctioning pituitary adenomas (NFPA) have a higher incidence of comorbidities than men with NFPA, according to a new data. Using the Swedish National Patient Registry, researchers identified 2,795 patients (1,502 men and 1,293 women) diagnosed with NFPA between 1997 and 2011. Compared with the general Swedish population, women with NFPA had a higher standardized incidence ratio (SIR) than men with NFPA for type 2 diabetes mellitus (SIR: women 2.9; men 2.2) and cerebral infarction (SIR: women 2.3; men 1.3). Women, but not men, with NFPA also had an increased incidence of myocardial infarction and fractures (SIR 1.7 and 1.8, respectively). Although the reason for the sex-specific differences is unclear, the findings highlight the need to monitor all patients diagnosed with NFPA, especially women, and to provide adequate preventative treatment.
Olsson, D. S. et al. Higher incidence of morbidity in women than men with non-functioning pituitary adenoma: a Swedish nationwide study. Eur. J. Endocrinol. http://dx.doi.org/10.1530/EJE-16-0173 (2016)
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Holmes, D. Sex difference in comorbidity burden associated with nonfunctioning pituitary adenomas. Nat Rev Endocrinol 12, 374 (2016). https://doi.org/10.1038/nrendo.2016.82