Year in Review | Published:

Healthy ageing in 2016

Obesity in geroscience — is cellular senescence the culprit?

Nature Reviews Endocrinology volume 13, pages 7678 (2017) | Download Citation

Obesity and ageing are major worldwide health challenges associated with lifestyle changes and an increase in age-related diseases, characterized by chronic inflammation dubbed metaflammation and inflammaging. However, the mechanistic link between these inflammatory processes is still unknown. New findings in 2016 shed light on these issues and indicate common targets for intervention.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    et al. Geroscience: linking aging to chronic disease. Cell 159, 709–713 (2014).

  2. 2.

    & Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. A Biol. Sci. Med. Sci. 69 (Suppl. 1), 4–9 (2014).

  3. 3.

    et al. Inflammaging and 'garb-aging'. Trends Endocrinol. Metab. (2016).

  4. 4.

    & Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 29, 415–445 (2011).

  5. 5.

    et al. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes 65, 1606–1615 (2016).

  6. 6.

    et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J. Clin. Invest. 126, 4626–4639 (2016).

  7. 7.

    et al. Aging of mice is associated with p16Ink4a- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells. Aging (Albany NY) 8, 1294–1315 (2016).

  8. 8.

    et al. Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle. Cell Rep. 14, 422–428 (2016).

  9. 9.

    et al. A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats. Sci. Rep. 6, 37278 (2016).

  10. 10.

    et al. Gut microbiota and extreme longevity. Curr. Biol. 26, 1480–1485 (2016).

Download references


This work was supported by the European Union (EU)'s H2020 Project 'Propag-ageing' (grant agreement no. 634821), EU FP7 “HUMAN”, G.A. n. 602757; and EU JPND 'Adage' to C.F.

Author information


  1. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Institute of Neurological Sciences of Bologna, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy.

    • Claudio Franceschi


  1. Search for Claudio Franceschi in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Claudio Franceschi.

About this article

Publication history



Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing