Exercise training has positive effects on disease risk and health outcomes through mechanisms that have not been fully characterized. Newly published data reveal that a single bout of exercise regulates the phosphoproteome via activation of a global network of kinases and 5′-AMP-activated protein kinase substrates — targets with therapeutic potential for chronic metabolic diseases.
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References
Booth, F. W., Gordon, S. E., Carlson, C. J. & Hamilton, M. T. Waging war on modern chronic diseases: primary prevention through exercise biology. J. Appl. Physiol. 88, 774–787 (2000).
Myers, J. et al. Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med. 346, 793–801 (2002).
Neufer, P. D. et al. Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. Cell Metab. 22, 4–11 (2015).
Hoffman, N. J. et al. Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates. Cell Metab. 22, 1–14 (2015).
Hawley, J. A., Hargreaves, M., Joyner, M. J. & Zierath, J. R. Integrative biology of exercise. Cell 159, 738–749 (2014).
Hawley, J. A. & Morton, J. P. Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clin. Exp. Pharmacol. Physiol. 41, 608–613 (2014).
Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8, 457–465 (2012).
Zierath, J. R. & Wallberg-Henriksson, H. Looking ahead perspective: where will the future of exercise biology take us? Cell Metab. 22, 25–30 (2015).
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Hawley, J., Krook, A. One step forward for exercise. Nat Rev Endocrinol 12, 7–8 (2016). https://doi.org/10.1038/nrendo.2015.201
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DOI: https://doi.org/10.1038/nrendo.2015.201
