New recommendations for the initial evaluation of infants or adolescents with a suspected disorder of sex development (DSD) have been published by the UK Society for Endocrinology. A UK DSD taskforce consisting of a range of clinical professionals, stakeholder professional societies and members of patient support and/or advocacy groups was formed in 2009 to provide guidance to clinical professionals who encounter infants or adolescents with a DSD, and to harmonize good clinical practice. The findings, published in Clinical Endocrinology, emphasize the importance of supporting the affected individual and their parents, assigning a sex of rearing and excluding the possibility of other early medical problems.