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  • Year in Review
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T1DM in 2014

Progress towards a bionic pancreas

Nature Reviews Endocrinology volume 11, pages 75–76 (2015)Cite this article

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2014 was a good year for developments in automated insulin delivery systems for patients with diabetes mellitus. Clinical trials shifted from research units to the outpatient setting, included both adult and adolescent individuals and were conducted over periods from overnight to 24 h, with improvements seen in time spent in the target glycaemic range and reduced risk of hypoglycaemia.

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References

  1. Bakhtiani, P. A., Zhao, L. M., El Youssef, J., Castle, J. R. & Ward, W. K. A review of artificial pancreas technologies with an emphasis on bi-hormonal therapy. Diabetes Obes. Metab. 15, 1065–1070 (2013).

    Article  CAS  Google Scholar 

  2. Kovatchev, B. P. et al. Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas. Diabetes Care 37, 1789–1796 (2014).

    Article  CAS  Google Scholar 

  3. Ly, T. T. et al. Overnight glucose control with an automated, unified safety system in children and adolescents with type 1 diabetes at diabetes camp. Diabetes Care 37, 2310–2316 (2014).

    Article  CAS  Google Scholar 

  4. Thabit, H. et al. Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. Lancet Diabetes Endocrinol. 2, 701–709 (2014).

    Article  CAS  Google Scholar 

  5. Nimri, R. et al. MD-Logic overnight control for 6 weeks of home use in patients with type 1 diabetes: randomized crossover trial. Diabetes Care 37, 3025–3032 (2014).

    Article  CAS  Google Scholar 

  6. Russell, S. J. et al. Outpatient glycemic control with a bionic pancreas in type 1 diabetes. N. Engl. J. Med. 371, 313–325 (2014).

    Article  Google Scholar 

  7. Weinzimer, S. A. et al. Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas. Diabetes Care 31, 934–939 (2008).

    Article  Google Scholar 

  8. Luijf, Y. M. et al. Day and night closed-loop control in adults with type 1 diabetes: a comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-management. Diabetes Care 36, 3882–3887 (2013).

    Article  CAS  Google Scholar 

  9. El-Khatib, F. H. et al. Autonomous and continuous adaptation of a bihormonal bionic pancreas in adults and adolescents with type 1 diabetes. J. Clin. Endocrinol. Metab. 99, 1701–1711 (2014).

    Article  CAS  Google Scholar 

  10. Frier, B. M. Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications. Nat. Rev. Endocrinol. 10, 711–722 (2014).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Suite 3054, Miami, 33136, FL, USA

    Jay S. Skyler

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  1. Jay S. Skyler
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Correspondence to Jay S. Skyler.

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Competing interests

J.S.S. is a Director of Dexcom and owns shares in Dexcom and Tandem Diabetes Care.

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Skyler, J. Progress towards a bionic pancreas. Nat Rev Endocrinol 11, 75–76 (2015). https://doi.org/10.1038/nrendo.2014.228

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