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Diabetes

Solving human β-cell development—what does the mouse say?

Nature Reviews Endocrinology volume 10, pages 253–255 (2014)Cite this article

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A genetic analysis of patients with permanent neonatal diabetes mellitus has revealed functional conservation of transcription factors critical for β-cell development in both mouse and man. This finding supports the use of mice for modelling human disease but also highlights the need for additional human-specific studies of β-cell function.

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Figure 1: Schematic of the study design and key results.

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Authors and Affiliations

  1. Department of Medicine, Diabetes Center, University of California-San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, 94143, CA, USA

    Alexandra E. Folias & Matthias Hebrok

Authors
  1. Alexandra E. Folias
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  2. Matthias Hebrok
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Correspondence to Matthias Hebrok.

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The authors declare no competing financial interests.

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Folias, A., Hebrok, M. Solving human β-cell development—what does the mouse say?. Nat Rev Endocrinol 10, 253–255 (2014). https://doi.org/10.1038/nrendo.2014.18

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