Ligand binding to the insulin and insulin-like growth factor 1 receptors activates the tyrosine kinase pathway. The unoccupied receptors can also generate signals that activate noncanonical pathways, which are poorly known. A new study reveals that expression of paternally and maternally imprinted genes and microRNAs is dowregulated in brown preadipocytes lacking both of the receptors. Inactivation of the insulin receptor has similar effects in mouse embryonic fibroblasts and in mouse brown adipose tissue in vivo.
References
Boucher, J. et al. Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. Proc. Natl Acad. Sci. USA 10.1073/pnas.1415475111
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New role of insulin and IGF-1 receptors in the expression of imprinted genes and microRNAs. Nat Rev Endocrinol 10, 702 (2014). https://doi.org/10.1038/nrendo.2014.177
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DOI: https://doi.org/10.1038/nrendo.2014.177