Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cardiovascular endocrinology

First-time heart failure increases risk of diabetes mellitus

Patients with diabetes mellitus have an increased risk of developing heart failure. In a recent study, people hospitalised for first-time heart failure also had an increased risk of developing type 2 diabetes mellitus (T2DM) that was positively associated with loop-diuretic dosage. These findings highlight the need for extra awareness of T2DM in such patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Andersson, C. et al. Heart failure severity, as determined by loop diuretic dosages, predicts the risk of developing diabetes after myocardial infarction: a nationwide cohort study. Eur. J. Heart Fail. 12, 1333–1338 (2010).

    Article  CAS  Google Scholar 

  2. Demant, M. N. et al. Association of heart failure severity with risk of diabetes: a Danish nationwide cohort study. Diabetologia http://dx.doi.org/10.1007/s00125-014-3259-z.

  3. Kannel, W. B. & McGee, D. L. Diabetes and cardiovascular disease. The Framingham study. JAMA 241, 2035–2038 (1979).

    Article  CAS  Google Scholar 

  4. McMurray, J. J. Gerstein, H. C., Holman, R. R. & Pfeffer, M. A. Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored. Lancet Diabetes Endocrinol. http://dx.doi.org/10.1016/S2213-8587(14)70031-2.

  5. Torp-Pedersen, C. et al. Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol Or Metoprolol European Trial (COMET). Heart 93, 968–973 (2007).

    Article  CAS  Google Scholar 

  6. Shen, L. et al. Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study. BMJ 347, f6745 (2013).

    Article  Google Scholar 

  7. Bosch, J. et al. Effect of ramipril on the incidence of diabetes. N. Engl. J. Med. 355, 1551–1562 (2006).

    Article  Google Scholar 

  8. Ashrafian, H., Frenneaux, M. P. & Opie, L. H. Metabolic mechanisms in heart failure. Circulation 116, 434–448 (2007).

    Article  CAS  Google Scholar 

  9. AlZadjali, M. A. et al. Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure. J. Am. Coll. Cardiol. 53, 747–753 (2009).

    Article  CAS  Google Scholar 

  10. Kenchaiah, S. et al. Body mass index and prognosis in patients with chronic heart failure: insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program. Circulation 116, 627–636 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rury R. Holman.

Ethics declarations

Competing interests

R.R.H. has received grants from Bristol–Myers Squibb, grants and personal fees from Bayer and Merck, and personal fees from Novartis and Janssen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Holman, R. First-time heart failure increases risk of diabetes mellitus. Nat Rev Endocrinol 10, 453–454 (2014). https://doi.org/10.1038/nrendo.2014.105

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2014.105

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing