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Type 2 diabetes mellitus in 2013

A central role of the gut in glucose homeostasis

Nature Reviews Endocrinology volume 10, pages 73–74 (2014)Cite this article

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Metabolic surgery has been proven to be effective in inducing remission of type 2 diabetes mellitus prior to any significant weight reduction. Studies in 2013 have investigated the mechanisms of action of these procedures and have highlighted a central role of the small intestine in the effects on glucose homeostasis.

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Figure 1: Activation of the gut–brain–liver neuronal axis under glucose and/or lipid stimulation via a nutrient sensor located in the proximal jejunum.

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Authors and Affiliations

  1. Department of Internal Medicine, Catholic University of Rome, Largo A. Gemelli 8, Rome, 00168, Italy

    Geltrude Mingrone

  2. Department of Surgery, Università La Sapienza, Viale Regina Elena 324, Rome, 00195, Italy

    Lidia Castagneto-Gissey

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  1. Geltrude Mingrone
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  2. Lidia Castagneto-Gissey
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Correspondence to Geltrude Mingrone.

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The authors declare no competing financial interests.

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Mingrone, G., Castagneto-Gissey, L. A central role of the gut in glucose homeostasis. Nat Rev Endocrinol 10, 73–74 (2014). https://doi.org/10.1038/nrendo.2013.241

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