Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epidemiology

Work-related stress and the risk of type 2 diabetes mellitus

A new cohort study links work-related stress to an increased risk of developing type 2 diabetes mellitus (T2DM) in women, but the findings are less clear in men. Randomized controlled studies are now needed to determine whether management of stress could be used to reduce the risk of developing T2DM.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Karasek, R., Baker, D., Marxer, F., Ahlbom, A. & Theorell, T. Job decision latitude, job demands, and cardiovascular disease: a prospective study of Swedish men. Am. J. Public Health 71, 694–705 (1981).

    Article  CAS  Google Scholar 

  2. Kivimäki, M. et al. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet 380, 1491–1497 (2012).

    Article  Google Scholar 

  3. Eriksson, A. K., van den Donk, M., Hilding, A. & Östenson, C. G. Work stress, sense of coherence, and risk of type 2 diabetes in a prospective study of middle-aged Swedish men and women. Diabetes Care http://dx.doi.org/10.2337/dc12-1738.

  4. Brunner, E. Biology and health inequality. PLoS Biol. 5, e267 (2007).

    Article  Google Scholar 

  5. Chida, Y. & Steptoe, A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol. Psychol. 80, 265–278 (2009).

    Article  Google Scholar 

  6. Heraclides, A. M., Chandola, T., Witte, D. R. & Brunner, E. J. Work stress, obesity and the risk of type 2 diabetes: gender-specific bidirectional effect in the Whitehall II study. Obesity (Silver Spring) 20, 428–433 (2012).

    Article  Google Scholar 

  7. Knowler, W. C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

    Article  CAS  Google Scholar 

  8. Steptoe, A. & Kivimäki, M. Stress and cardiovascular disease: an update on current knowledge. Ann. Rev. Public Health 34, 337–354 (2013).

    Article  Google Scholar 

  9. Ioannidis, J. P. et al. Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA 286, 821–830 (2001).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

E. J. Brunner's research is supported by the British Heart Foundation (RG/13/2/30098). M. Kivimäki's work is supported by the Medical Research Council (K013351), the NIH (HL36310 and AG034454) and a professorial fellowship from the Economic and Social Research Council.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric J. Brunner.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brunner, E., Kivimäki, M. Work-related stress and the risk of type 2 diabetes mellitus. Nat Rev Endocrinol 9, 449–450 (2013). https://doi.org/10.1038/nrendo.2013.124

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2013.124

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing