Hypopituitarism, including growth hormone (GH) deficiency, is accompanied by increased morbidity and mortality. These factors may be due to the underlying disease and treatments such as surgery or radiotherapy, but can also arise from GH substitution therapy at nonphysiological doses. Nevertheless, emerging long-term data on GH replacement therapy now indicate benefits for bone health.
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A. P. Jørgensen declares associations with the following companies: Novartis (speakers bureau), Novo Nordisk (speakers bureau; grant/research support), Merck Serono (speakers bureau; grant/research support), Pfizer (speakers bureau; grant/research support). J. Bollerslev declares he has received grant/research support from the following companies: Novartis, Novo Nordisk, Merck Serono, Pfizer.
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Jørgensen, A., Bollerslev, J. Growth hormone replacement—implications for bone health. Nat Rev Endocrinol 8, 325–326 (2012). https://doi.org/10.1038/nrendo.2012.50
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DOI: https://doi.org/10.1038/nrendo.2012.50
