The extraskeletal benefits and harms of supplementation with calcium and vitamin D are unknown. The RECORD trial compared overall, vascular and cancer mortality and cancer incidence by supplement use and found no evidence of any harm or benefit. However, compliance was poor and serum 25-hydroxyvitamin D levels were low.
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S. A. Jamal declares associations with the following companies: Amgen (speakers bureau), Genzyme (consultant, speakers bureau), Novartis (consultant, speakers bureau), Shire (consultant, speakers bureau), Warner Chilcott (consultant, speakers bureau). S. Velasco declares no competing interests.
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Velasco, S., Jamal, S. Calcium and vitamin D for extraskeletal health—jury is out. Nat Rev Endocrinol 8, 132–133 (2012). https://doi.org/10.1038/nrendo.2012.10
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DOI: https://doi.org/10.1038/nrendo.2012.10
