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Diabetes

Insulin signal meets SIRT1 at AKT

Nature Reviews Endocrinology volume 8, pages 131–132 (2012)Cite this article

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Insulin resistance is a characteristic feature of type 2 diabetes mellitus. The activation of SIRT1, a deacetylase, is reported to be very beneficial for the treatment of type 2 diabetes mellitus in animal models. Recent reports reveal the mechanisms by which insulin signaling might be targeted by SIRT1.

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Figure 1: The complex mTORC2 suppresses gluconeogenesis by phosphorylating and activating AKT.

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  1. Department of Pharmacology, Sapporo Medical University, S1 W17, Chu-ouku, 060-8556, Sapporo, Japan

    Yoshiyuki Horio

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  1. Yoshiyuki Horio
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Horio, Y. Insulin signal meets SIRT1 at AKT. Nat Rev Endocrinol 8, 131–132 (2012). https://doi.org/10.1038/nrendo.2011.208

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