A recent study of selenium supplementation in patients with mild Graves ophthalmopathy (GO) has demonstrated improvements in associated soft-tissue manifestations of the disease. The findings of this multicenter trial reveal a potential treatment option for the mild form of this vexing disease, which affects the majority of patients with GO.
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References
Bahn, R. S. Graves' ophthalmopathy. N. Engl. J. Med. 362, 726–738 (2010).
Marcocci, C. et al. Selenium and the course of mild Graves' orbitopathy. N. Engl. J. Med. 364, 1920–1931 (2011).
Kryukov, G. V., et al. Characterization of mammalian selenoproteomes. Science 300, 1439–1443 (2003).
Puertollano, M. A., Puertollano, E., de Cienfuegos, G. A. & de Pablo, M. A. Dietary antioxidants: immunity and host defense. Curr. Top. Med. Chem. 11, 1752–1766 (2011).
Stoedter, M., Renko, K., Hog, A. & Schomburg, L. Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice. Biochem. J. 429, 43–51 (2010).
Windmeier, C. & Gressner, A. M. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen. Pharmacol. 29, 181–196 (1997).
Henstrom, D. K, Lindsay, R. W, Cheney, M. L. & Hadlock, T. A. Surgical treatment of the periocular complex and improvement of quality of life in patients with facial paralysis. Arch. Facial Plast. Surg. 13, 125–128 (2011).
European Group on Graves' Orbitopathy (EUGOGO) et al. Outcome of orbital decompression for disfiguring proptosis in patients with Graves' orbitopathy using various surgical procedures. Br. J. Ophthalmol. 93, 1518–1523 (2009).
Elsom, R. et al. Functional markers of selenium status: UK Food Standards Agency workshop report. Br. J. Nutr. 96, 980–984 (2006).
Sayar, K. et al. Dietary selenium and vitamin E intakes alter β-adrenergenic response of L-type Ca-current and β-adrenoceptor-adenylate cyclase coupling in rat heart. J. Nutr. 130, 733–740 (2000).
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Smith, T., Douglas, R. Does selenium supplementation improve Graves ophthalmopathy?. Nat Rev Endocrinol 7, 505–506 (2011). https://doi.org/10.1038/nrendo.2011.128
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DOI: https://doi.org/10.1038/nrendo.2011.128
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