Cancer

Small papillary thyroid cancers—is BRAF of prognostic value?

Nature Reviews Endocrinology volume 7, pages9–10(2011)Cite this article

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The growing incidence in thyroid cancer results mainly from the detection of small or very small papillary thyroid carcinomas. The management of patients with such small tumors represents a major clinical challenge. Could evaluation of the BRAF status of such tumors aid risk stratification and patient management?

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References

  1. 1

    Basolo, F. et al. Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases. J. Clin. Endocrinol. Metab. 95, 4197–4205 (2010).

  2. 2

    Soares, P. et al. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 22, 4578–4580 (2003).

  3. 3

    Rhoden, K. J. et al. RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma. J. Clin. Endocrinol. Metab. 91, 2414–2423 (2006).

  4. 4

    Xing, M. et al. BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer. J. Clin. Oncol. 27, 2977–2982 (2009).

  5. 5

    Trovisco, V. et al. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J. Pathol. 202, 247–251 (2004).

  6. 6

    Castro, P., Fonseca, E., Magalhães, J. & Sobrinho-Simões, M. Follicular, papillary, and “hybrid” carcinomas of the thyroid. Endocr. Pathol. 13, 313–320 (2002).

  7. 7

    Trovisco, V. et al. Type and prevalence of BRAF mutations are closely associated to papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. Virchows Arch. 446, 589–595 (2005).

  8. 8

    Castro, P. et al. PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. J. Clin. Endocrinol. Metab. 91, 213–220 (2006).

  9. 9

    Ugolini, C. et al. Presence of BRAF V600E in very early stages of papillary thyroid carcinoma. Thyroid 17, 381–388 (2007).

  10. 10

    Xing, M. BRAF mutation in papillary thyroid microcarcinoma: the promise of better risk management. Ann. Surg. Oncol. 16, 801–803 (2009).

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  1. Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Roberto Frias s/n, Porto, 4200-465, Portugal
    • Paula Soares
    •  & Manuel Sobrinho-Simões
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  1. Paula Soares
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  2. Manuel Sobrinho-Simões
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Correspondence to Manuel Sobrinho-Simões.

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The authors declare no competing financial interests.

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Soares, P., Sobrinho-Simões, M. Small papillary thyroid cancers—is BRAF of prognostic value?. Nat Rev Endocrinol 7, 9–10 (2011). https://doi.org/10.1038/nrendo.2010.213

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