Although low-grade inflammation of adipose tissue is thought to be central to the development of insulin resistance in individuals with obesity, the underlying cause of this inflammatory state remains elusive. A new study by Kos and colleagues suggests that the glycoprotein SPARC limits adipose-tissue expansion and promotes inflammation and insulin resistance.
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Naïmi, M., Van Obberghen, E. Where is the SPARC in adipose-tissue inflammation?. Nat Rev Endocrinol 5, 648–649 (2009). https://doi.org/10.1038/nrendo.2009.220
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DOI: https://doi.org/10.1038/nrendo.2009.220
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